Which syndrome is characterized by uveitis, parotitis, chronic fever, and facial nerve paralysis?

Heerfordt syndrome, also known as uveoparotid fever, is a specific manifestation of sarcoidosis. It is characterized by a combination of uveitis (inflammation of the uvea in the eye), parotitis (inflammation of the parotid gland), chronic fever, and facial nerve paralysis. This collection of symptoms leads to the unique clinical picture associated with this syndrome, making it particularly distinctive among inflammatory conditions.

The presence of uveitis points to ocular involvement, which is a common feature in systemic inflammatory diseases, but the combination with parotitis and facial nerve involvement strongly suggests Heerfordt syndrome as a diagnosis. The acute onset of these symptoms often correlates with the systemic nature of sarcoidosis, which can affect multiple organ systems.

In contrast, Sjogren's syndrome primarily involves xerostomia and keratoconjunctivitis sicca (dry eyes), with salivary and lacrimal gland involvement, typically without the combination of facial nerve paralysis and uveitis seen in Heerfordt syndrome. Behçet's syndrome is characterized by oral and genital ulcers, uveitis, and systemic vasculitis without a typical presentation of parotitis. Stevens-Johnson