Which medication is used as pre-operative treatment for severe type III Von Willebrand's disease?

The correct choice is the infusion of Von Willebrand factor and Factor VIII for the pre-operative treatment of severe type III Von Willebrand's disease. This condition is characterized by a deficiency in both Von Willebrand factor (vWF) and Factor VIII, leading to significant bleeding risk due to impaired platelet function and coagulation cascade participation.

In this case, the administration of Von Willebrand factor helps restore normal platelet function and stabilize Factor VIII, correcting the coagulopathy associated with the disease. This therapy is crucial in the pre-operative setting since patients with type III Von Willebrand's disease are at high risk for excessive bleeding during surgical procedures. By providing the deficient factors directly, the likelihood of hemostatic success during and after surgery is maximized.

While desmopressin (DDAVP) can be effective in some patients with milder forms of Von Willebrand's disease by stimulating the release of vWF from endothelial cells, it is not suitable for those with severe type III where there is an absolute deficiency of vWF. Similarly, Factor IX concentrate is primarily used for Hemophilia B, making it inappropriate for treatment of Von Willebrand's disease. Cryoprecipitate, which contains fibrinogen and clotting factors, may