Which inhalation agent should not be used on children?

Desflurane is generally not recommended for use in children primarily due to its pungent odor and irritating properties, which can lead to adverse respiratory effects. Inhalation agents, especially in the pediatric population, should ideally have a pleasant smell to facilitate ease of induction. Desflurane's characteristics may cause coughing, breathholding, or even laryngospasm in children, making it less suitable for this demographic.

In contrast, agents like halothane, isoflurane, and sevoflurane are more commonly used in pediatric anesthetic practice. Halothane, although less frequently used now, has a smoother induction profile. Isoflurane is also considered safe for children, while sevoflurane is particularly favored due to its non-irritating qualities and favorable pharmacokinetics, leading to rapid induction and recovery times without significant respiratory irritation. The preference for sevoflurane in pediatric cases is due to its low blood/gas solubility and pleasant odor, making it a suitable choice for inducing anesthesia in children.