Which cytokine is a good indicator of a healthy TMJ?

The choice of IL-10 as a good indicator of a healthy temporomandibular joint (TMJ) is based on its role as an anti-inflammatory cytokine. IL-10 is known for its ability to suppress inflammatory responses and promote tissue healing. In the context of the TMJ, the presence of IL-10 suggests an environment that is favorable to tissue homeostasis and repair, indicating a balanced immune response and a healthy joint.

High levels of pro-inflammatory cytokines, such as IL-1 and IL-6, are typically associated with inflammation and degeneration in the TMJ, which can lead to disorders such as arthritis or other degenerative conditions. IL-12, while important in driving immune responses, does not have the same relevance to joint health as IL-10 does in reducing inflammation and promoting healing. Therefore, IL-10's role in mediating an anti-inflammatory environment makes it a key indicator of TMJ health.