Which characteristic facial feature is associated with DiGeorge syndrome?

DiGeorge syndrome, also known as 22q11.2 deletion syndrome, is characterized by a variety of facial features that result from the congenital heart defects, immune deficiencies, and other developmental issues associated with the condition. One of the hallmark facial characteristics is a prominent nose with a rounded tip. This feature is often recognized in patients with the syndrome and can be used as a diagnostic clue when assessing individuals with DiGeorge syndrome.

The rounded tip of the nose and prominence are typically viewed alongside other facial features that may include a flat nasal bridge, which contributes to the overall appearance associated with this genetic disorder. These facial characteristics arise due to the developmental implications of the genetic anomaly affecting the structures originating from the third and fourth pharyngeal pouches.

Other features commonly seen in DiGeorge syndrome, though not the main focus of recognition, include a wide-set appearance of the eyes, which can sometimes be confused with other conditions. However, the distinctive prominence of the nose with a rounded tip is one of the more specific indicators tied directly to the syndrome, making it a significant point in clinical identification.