What is the primary association of endemic Burkitt's lymphoma?

Endemic Burkitt's lymphoma is primarily associated with Epstein-Barr virus (EBV) infection. This subtype of Burkitt's lymphoma is most commonly found in children in certain regions of Africa and is often linked to the presence of EBV, which is known to play a significant role in the pathogenesis of the disease. The virus is thought to contribute to the malignant transformation of B-lymphocytes, leading to the rapid proliferation characteristic of this lymphoma.

In the context of Burkitt's lymphoma, EBV is particularly notable for being present in a large percentage of endemic cases, as opposed to sporadic forms of Burkitt's lymphoma, where the association is less pronounced. The virus's influence on immune regulation and cell transformation underlies its role in this cancer.

While other factors such as non-Hodgkin's lymphoma is a broader category that includes Burkitt's lymphoma, and HIV can also be linked to lymphoproliferative disorders, they do not have the specific primary association seen with EBV in endemic cases of Burkitt's lymphoma. Pesticide exposure has been investigated in various health contexts, but it lacks a direct association with this specific lymphoma subtype. Thus, the connection with EBV remains