What condition increases the risk of non-Hodgkin lymphoma?

The association between sarcoidosis and an increased risk of non-Hodgkin lymphoma is supported by various studies suggesting that the chronic inflammatory state and immune dysregulation that characterize sarcoidosis may play a role in the development of hematologic malignancies, including lymphomas. Sarcoidosis is known for the formation of granulomas, which can lead to persistent immune activation. This heightened immune activity can contribute to a higher risk of malignancies, including various forms of lymphoma, as the normal regulatory mechanisms are disrupted.

In contrast, diabetes mellitus, hypertension, and asthma are not consistently associated with an increased risk of non-Hodgkin lymphoma. While these conditions have their own complications and associations with other diseases, they do not significantly correlate with the development of lymphomas in the way that sarcoidosis does. The chronic inflammatory processes and changes in lymphatic and immune system functions in sarcoidosis distinctly contribute to this elevated risk, making it the most relevant option in this context.