In older adults, which area of the body is associated with the most significant volume loss?

The most significant volume loss in older adults is associated with facial structures. As individuals age, there are several changes that occur in the facial anatomy, primarily due to the loss of subcutaneous fat, alterations in collagen and elastin, and decreased bone density, particularly in the maxilla and mandible. This progressive loss of volume in the facial soft tissues contributes to a more aged appearance, characterized by skin sagging, prominent nasolabial folds, and a less defined jawline.

These changes affect not only aesthetics but also functional aspects, such as oral health and dentition. The impact of volume loss in the facial region is profound because it is a central area of social interaction and can significantly influence self-esteem and psychological well-being.

While bone density, upper extremities, and liver mass also undergo changes with age, the facial structures are uniquely noticeable and directly correlate with the visual perception of aging, making this option particularly relevant.